Multidrug Resistance 1 MDR1 Test

A health screening test for your dog to determine if it carries the mutated MDR1 gene.

AffinityDNA DNA Helix Icon Multidrug Resistance 1 MDR1 Test

What is Multidrug Resistance 1?

Multidrug Resistance 1 is inherited as an autosomal incomplete dominant disease. The MDR1 gene codes for the production of a protein known as p-glycoprotein. P-glycoprotein acts as a pump that removes certain drugs and toxins from the body. A mutation in the ABCB1 gene associated with MDR1 prohibits P-glycoprotein’s ability to limit absorption, distribution, and excretion of drugs and allows higher levels of drugs to enter the brain.

Dogs only need to inherit one copy of the MDR1 mutation to be at risk for sensitivity to certain drugs. Dogs with two copies of the MDR1 mutation can have more severe reactions such as excess salivation, tremors, anorexia, blindness and possibly death.

MDR1 affected dogs are at risk of developing neurologic symptoms from several common drugs including Acepromazine (tranquiliser), Butorphanol (pain control), Doramectin, Doxorubicin, Emodepside, Erythromycin, Ivermectin (found in heartworm medications), Loperamide (anti-diarrheal agent), Milbemycin, Moxidectin, Paclitaxel, Rifampicin, Selamectin, Vinblastine (anti-cancer agent), Vincristine and Vinorelbine.

Other medications may also cause a reaction and you should inform your veterinarian if your dog is a MDR1-carrier or MDR1-affected so they can adjust dosage or provide an alternative medication.

AffinityDNA DNA Helix Icon Multidrug Resistance 1 MDR1 Test

Which Breeds Can Be Tested for Multidrug Resistance 1 MDR1?

The Multidrug Resistance 1 MDR1 Test can be carried out on all breeds.

AffinityDNA DNA Helix Icon Multidrug Resistance 1 MDR1 Test

What will Multidrug Resistance 1 MDR1 Test Results Tell You?

Using a simple swab from the inner cheek of your dog, we will ascertain whether your dog carries the mutated MDR1 gene, which allows you to make an informed choice as to whether or not to breed from the dog.

Once we receive the dog’s buccal swabs, we undertake tests that will give one of three possible outcomes:

  1. A CLEAR result shows that the dog has inherited two genes from its parents that are mutation free and will not be affected by MDR1.
  2. A CARRIER result indicates that the dog has inherited one normal copy of the MDR1 gene, and one mutation. This means that the dog has an increased risk of drug sensitivity.
  3. An AFFECTED result indicates that the dog has inherited two copies of the mutated MDR1 gene from its parents and is at risk of adverse drug reactions.

Please click on the image below to view our Multidrug Resistance 1 MDR1 Test Result Chart:

Multidrug Resistance 1 MDR1 Test Result Chart

AffinityDNA DNA Helix Icon Multidrug Resistance 1 MDR1 Test

Other Dog DNA Tests from AffinityDNA

As well as the Multidrug Resistance 1 MDR1 Test we also offer a range of inherited disease screening tests including:

Dog Allergy Testing, Dog Parentage Testing and a choice of dog DNA breed tests which include information about the personality traits and predisposition to diseases for each breed found in your dog’s DNA.

If you have any questions about the Multidrug Resistance 1 MDR1 Test for your dog, please do not hesitate to Contact our Customer Service Team who will be happy to help you.


Home Paternity Test Review
Perfect 🙂 Thank you!
April 2024
Dog Breed Identification Test Review
Quick delivery well packed just got results today very happy with this service
April 2024
Prenatal Paternity Test Review
Thank you so much for the great service and fast results
March 2024
Ancestry DNA Test Review
The expertise extant in your organisation is obvious in your reporting and I am so pleased that I decided not to go with some other, ‘popular’ option.
March 2024
Degenerative Myelopathy Test Review
Amazing very fast delivery and so much detailed information!
March 2024
Immigration DNA Testing Review
Thank you very much for your very prompt and professional service.
February 2024
DogCheck 4.0 Genetic Disease Test Feedback
Very fast delivery & results, would highly recommend it
February 2024
Siblingship DNA Test Review
Thank you so much for your great service and speed. Much appreciated.
January 2024
AffinityDNA Review for Home DNA Testing Kits
The care by the lab was second to none, they kept my son updated all the way.
January 2024
Paternity Test Kits Review
Thank you so much for your help with this. A very professional and caring service. Reminds me how very different customer services are in UK compared to the service accepted by most people here in Spain. Thanks again.
January 2024
Dog Allergy Testing Kit Review
Hello Team, I would love to thank all involved in testing my dog allergies. Since that test she finally lives her life itch free as it enabled us to avoid products causing her allergic reaction. I am very grateful for this report as her health massively improved after we removed all listed products from her diet. Since that time I have been suggesting other dog owners which battle similar issue to use your service. 5* from Blue.
October 2022
Baby Gender Test Review
Thank you so much for sharing the results with me. I am really happy and impressed with your team's service and quick responses all the time. Affinity DNA service is really impressive and I must recommend this to my friends and family. 🙂
June 2022
Siblings DNA Test Review
Thank you so much for your quick reply and explanation it’s very much appreciated and thank you for the great work you guys do.
April 2022
DM DNA Test for Dogs Review
Thank you! Honestly, your quick response and helpfulness has been a breath of fresh air.
March 2022
DNA My Dog Results Review
Wowwwww thank you sooooo much for the results, looking at each individual breed you can piece together all her traits and stances. THANK YOU SOOOO MUCH.... well happy ?
January 2022
Forensic DNA Testing Review
I’ve just received the results. Your service has been impeccable. I really appreciate all your help, thank you so much.
October 2021
Home Paternity Testing Kit Review
Thank you very much for this! I appreciate your email and your result! This has brought a huge relief, tears to eyes! Thankyou for your service! Worth every penny if not more!
October 2021
Dog Allergy Test Kit Review
We had our dog allergy tested with you last year. We were advised that it is not a good enough test by our vet and many others online. This however couldn't be more wrong. We used the results to remove foods from her diet and even hypo-allergenic shampoos etc. Since she turned 1 years old we had her allergy tested by blood at the vet to see if she had out grown any of these allergies. The results were exactly the same as we were given by yourselves. Everything in red she is still allergic to. Without your help I'm not sure how we would of been able to help her in her first year. Especially given that she is allergic to almost everything hypoallergenic.
September 2021
Dog Allergy Testing Review
Please forward my praise to your superiors with regards to your customer attention - thank you for all the communication at all times, and making sure all OK. Much appreciated. 1 day into eliminating salmon oil from her diet (daily supplement I was giving her for for her arthritis) and the turkey menus she is considerably better, all in 24 hrs. Can’t wait to see how she improves within a few weeks of elimination.
April 2021
Paternity DNA Test Kit Review
You guys have honestly just kick started my life!! I’m buzzing
March 2021